Resident Evil: Degeneration takes place 7 years after the "Umbrella Incident" that took place in Raccoon City, which ended with the eradication of the deadly virus by a missile attack ordered by the government. As its operations were suspended on a global scale, Umbrella Corporation stock plummeted. This serious blow to the business giant resulted in its complete dissolution. 7 years later, at an airport somewhere in the United States, on an ordinary autumn afternoon, one zombie is unleashed into this peaceful scene to attack everyone. In the airport starting to fill up with the undead, the horrific disaster is about to be repeat itself.